ICR (CD-1^®) Mice: The Versatile Workhorses of Biomedical Research

ICR ICR (CD-1^®) outbred mice, originally derived from Swiss albino mice, are widely used in biomedical research due to their high reproductive performance, rapid growth, and strong adaptability to environment. These mice serve as excellent models in a broad range of research fields, including aging, toxicology, pharmacology, oncology, immunology, and vaccine research. Their robust health and genetic variability closely mirror the genetic diversity found in human populations, making them highly valuable in the field of medical research.

For more ICR mouse information, technical data, and pricing, please visit our stock-specific resources page:

Hsd:ICR (CD-1^®)

Applications of ICR Mice in Toxicology Research

In the sphere of toxicology research, ICR (CD-1^®) outbred mice serve as a premier model due to their significant physiological resilience and genetic diversity. Their susceptibility to a wide variety of toxic agents offers researchers the opportunity to study not only the acute effects but also the chronic consequences of exposure to these substances. ICR mice are frequently employed in the testing of new drugs and chemicals to evaluate potential human health risks. Their robust health status equips them to withstand long-term studies, providing invaluable insights into the cumulative impacts of toxin exposure. Furthermore, the genetic variation within the ICR outbred population allows for the assessment of inter-individual differences in response to toxic agents, offering a closer approximation to human genetic diversity and response variability.

ICR mice have established themselves as a valuable model in the field of biomedical research due to several distinct features. Firstly, they exhibit a high reproduction rate with large litter sizes. Secondly, they have excellent immune responses, making them ideal for immunology related studies. Thirdly, ICR mice also showcase a robust health status and adaptability to a variety of environments. The genetic diversity of the ICR strain also provides a more realistic representation of the genetic diversity found in human populations. Lastly, they are a cost-effective choice, which is particularly important in large-scale, long-term studies.

ICR (CD-1^®) Mice in Infectious Disease Research

In the realm of infectious disease research, ICR (CD-1^®) mice are a versatile model due to their robust immune response and genetic diversity. They have been extensively utilized for studies related to a wide range of pathogens—from bacteria and viruses to parasites. These mice are particularly indispensable in research on infectious diseases that have a substantial genetic component to susceptibility. For instance, ICR mice have been used to explore host-pathogen interactions, disease progression, and potential vaccines and treatment options for conditions such as malaria, West Nile, Zika virus, and tuberculosis. The genetic diversity within the ICR population helps model the different responses to infections seen in human populations, contributing to the development of more effective and personalized treatment strategies. However, as with all models, researchers must consider the limitations and ensure their study design accounts for any potential confounding factors.

Genetic Characteristics of ICR Mice

ICR (CD-1^®) outbred mice exhibit remarkable genetic diversity, a critical factor that elevates their utility in biomedical research. This genetic diversity mirrors the heterogeneity found in human populations, thereby rendering them suitable for studies aiming to understand the effects of genetic variances on disease susceptibility and drug responses. The ICR mice are an outbred stock, meaning they have more genetic variation as compared to inbred strains, much like humans in a population. Furthermore, the genetic variation in ICR mice also provides unique insights into the role of genetics in individual responses to toxic agents, new drugs, and the development of personalized medicines.

This mouse strain is known for its albino coat, which is characterized by a lack of pigmentation. Along with its striking appearance, these mice have a docile disposition, making them easy to handle and work with in research settings. Additionally, they exhibit excellent reproductive and maternal characteristics, making them ideal for breeding studies.

However, it's important to note that this mouse stock also has a high incidence of retinal degeneration caused by the Pde6b^rd1Pde6brd1 mutation. Researchers should consider this when designing experiments involving visual function. Despite this genetic predisposition, these mice have a relatively large litter average of 11.5, which contributes to their popularity as a widely-used outbred mouse strain in various research fields.

The Origin of ICR Mice

Hsd:ICR (CD-1^®) mouse model originated in Switzerland and traces back to two male and seven female albino non-inbred mice that were imported from Lausanne in 1926 by the Rockefeller Institute. Descendants of these mice were distributed globally, and in 1948, the Ha/ICR strain was established at the Institute of Cancer Research (ICR). A portion of the Ha/ICR colony was later transferred to the Roswell Park Memorial Institute (RPMI). In 1959, Charles River Laboratories (CRL) obtained their breeding nucleus from RPMI and performed caesarean rederivation. Harlan acquired breeding stock from CRL in 1983. Harlan subsequently rebranded as Envigo in 2015, then Envigo was acquired by Inotiv in 2021.

Characteristics

Coat: Albino
Docile disposition
Excellent reproductive and maternal characteristics
High incidence of retinal degeneration (Pde6b^rd1)
Litter Average: 11.5
Most widely-used outbred mouse

ICR (CD-1^®) outbred mice publications

ADMET

Pohjanvirta R, Mahiout S., Aryl hydrocarbon receptor is indispensable for β-naphthoflavone-induced novel food avoidance and may be involved in LiCl-triggered conditioned taste aversion in rats., Physiol Behav. 2019 May 15;204:58-64.

Harrill JA, Layko D, Nyska A, Hukkanen RR, Manno RA, Grassetti A, Lawson M, Martin G, Budinsky RA, Rowlands JC, Thomas RS., Aryl hydrocarbon receptor knockout rats are insensitive to the pathological effects of repeated oral exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin., J Appl Toxicol. 2016 Jun;36(6):802-14.

Phadnis-Moghe AS, Chen W, Li J, Crawford RB, Bach A, D'Ingillo S, Kovalova N, Suarez-Martinez JE, Kaplan BL, Harrill JA, Budinsky R, Rowlands JC, Thomas RS, Kaminski NE., Immunological characterization of the aryl hydrocarbon receptor (AHR) knockout rat in the presence and absence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)., Toxicology. 2016 Aug 10;368-369:172-182.

Harrill JA, Hukkanen RR, Lawson M, Martin G, Gilger B, Soldatow V, Lecluyse EL, Budinsky RA, Rowlands JC, Thomas RS., Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18

Aging

Bolles, M., Deming, D., Long, K., Agnihothram, S., Whitmore, A., Ferris, M., . . . Baric, R. S. (2011)., A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge, Journal of Virology, 85(23), 12201-12215. doi:10.1128/JVI.06048-11 [doi]

Corsetti, G., Pasini, E., Romano, C., Calvani, R., Picca, A., Marzetti, E., . . . Dioguardi, F. S. (2018)., Body weight loss and tissue wasting in late middle-aged mice on slightly imbalanced Essential/Non-essential amino acids diet., Frontiers in Medicine, 5, 136. doi:10.3389/fmed.2018.00136 [doi]

Rockx, B., Baas, T., Zornetzer, G. A., Haagmans, B., Sheahan, T., Frieman, M., . . . Katze, M. G. (2009), Early upregulation of acute respiratory distress syndrome-associated cytokines promotes lethal disease in an aged-mouse model of severe acute respiratory syndrome coronavirus infection, Journal of Virology, 83(14), 7062-7074. doi:10.1128/JVI.00127-09 [doi]

Barone, R., Macaluso, F., Catanese, P., Marino Gammazza, A., Rizzuto, L., Marozzi, P., . . . Di Felice, V. (2013)., Endurance exercise and conjugated linoleic acid (CLA) supplementation up-regulate CYP17A1 and stimulate testosterone biosynthesis, PloS One, 8(11), e79686. doi:10.1371/journal.pone.0079686 [doi]

Clayton, E. H., Garbow, J. R., & Bayly, P. V. (2011)., Frequency-dependent viscoelastic parameters of mouse brain tissue estimated by MR elastography, Physics in Medicine and Biology, 56(8), 2391-2406. doi:10.1088/0031-9155/56/8/005 [doi]

Cayatte, C., Snell Bennett, A., Rajani, G. M., Hostetler, L., Maynard, S. K., Lazzaro, M., . . . Schneider-Ohrum, K. (2017)., Inferior immunogenicity and efficacy of respiratory syncytial virus fusion protein-based subunit vaccine candidates in aged versus young mice., PloS One, 12(11), e0188708. doi:10.1371/journal.pone.0188708 [doi]

Grizenkova, J., Akhtar, S., Brandner, S., Collinge, J., & Lloyd, S. E. (2014), Microglial Cx3cr1 knockout reduces prion disease incubation time in mice., BMC Neuroscience, 15, 44-2202-15-44. doi:10.1186/1471-2202-15-44 [doi]

Antibody production

Rijal P, Wang BB, Tan TK, Schimanski L, Janesch P, Dong T, McCauley JW, Daniels RS, Townsend AR, Huang KA., Broadly Inhibiting Antineuraminidase Monoclonal Antibodies Induced by Trivalent Influenza Vaccine and H7N9 Infection in Humans, J Virol. 2020 Jan 31;94(4):e01182-19. doi: 10.1128/JVI.01182-19. Print 2020 Jan 31.

McKitrick TR, Goth CK, Rosenberg CS, Nakahara H, Heimburg-Molinaro J, McQuillan AM, Falco R, Rivers NJ, Herrin BR, Cooper MD, Cummings RD., Development of smart anti-glycan reagents using immunized lampreys, Commun Biol. 2020 Feb 28;3(1):91. doi: 10.1038/s42003-020-0819-2.

Boyoglu-Barnum S, Hutchinson GB, Boyington JC, Moin SM, Gillespie RA, Tsybovsky Y, Stephens T, Vaile JR, Lederhofer J, Corbett KS, Fisher BE, Yassine HM, Andrews SF, Crank MC, McDermott AB, Mascola JR, Graham BS, Kanekiyo M., Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses, Nat Commun. 2020 Feb 7;11(1):791. doi: 10.1038/s41467-020-14579-4.

Hemon MF, Lambert NC, Arnoux F, Roudier J, Auger I., PAD4 Immunization Triggers Anti-Citrullinated Peptide Antibodies in Normal Mice: Analysis With Peptide Arrays, Front Immunol. 2022 Mar 31;13:840035. doi: 10.3389/fimmu.2022.840035. eCollection 2022.

Atherosclerosis

Sijbesma JWA, van Waarde A, Kristensen S, Kion I, Tietge UJF, Hillebrands JL, Bulthuis MLC, Buikema H, Nakladal D, Westerterp M, Liu F, Boersma HH, Dierckx RAJO, Slart RHJA, Characterization of a novel model for atherosclerosis imaging: the apolipoprotein E-deficient rat, EJNMMI Res. 2023 Dec 11;13(1):106. doi: 10.1186/s13550-023-01055-5.

Berenji Ardestani S, Eftedal I, Pedersen M, Jeppesen PB, Nørregaard R, Matchkov VV., Endothelial dysfunction in small arteries and early signsÂ of atherosclerosis in ApoE knockout rats, Sci Rep. 2020 Sep 17;10(1):15296. doi: 10.1038/s41598-020-72338-3.

Berenji Ardestani S, Matchkov VV, Hansen K, Jespersen NR, Pedersen M, Eftedal I., Extensive Simulated Diving Aggravates Endothelial Dysfunction in Male Pro-atherosclerotic ApoE Knockout Rats, Front Physiol. 2020 Dec 23;11:611208. doi: 10.3389/fphys.2020.611208. eCollection 2020.

Wu, Y.; Johnson, G.; Zhao, F.; Wu, Y.; Zhao, G.; Brown, A.; You, S.; Zou, M.-H.; Song, P., Features of Lipid Metabolism in Humanized ApoE Knockin Rat Models, International Journal of Molecular Sciences. 2021; 22(15):8262.

Yang, J. H., Niu, W., Li, Y., & Azadzoi, K. M., Impairment of AMPK-?2 augments detrusor contractions in bladder ischemia, Investigative and Clinical Urology 62, no. 5 (2021): 600.

Nguyen TD, Watanabe A, Burleigh S, Ghaffarzadegan T, Kanklai J, Prykhodko O, Hållenius FF, Nyman M., Monobutyrin and monovalerin improve gut-blood-brain biomarkers and alter gut microbiota composition in high-fat fed apolipoprotein-E-knockout rats., Psychopharmacology (Berl). 2023 Jan;240(1):137-147. doi: 10.1007/s00213-022-06286-3. Epub 2022 Dec 5.

Nakladal, D., Sijbesma, J. W. A., Visser, L. M., Tietge, U. J. F., Slart, R. H. J. A., Deelman, L. E., ... & Buikema, H., Perivascular adipose tissue-derived nitric oxide compensates endothelial dysfunction in aged pre-atherosclerotic apolipoprotein E-deficient rats, Vascular pharmacology (2021): 106945.

Nakladal D, Sijbesma JWA, Visser LM, Tietge UJF, Slart RHJA, Deelman LE, Henning RH, Hillebrands JL, Buikema H., Perivascular adipose tissue-derived nitric oxide compensates endothelial dysfunction in aged pre-atherosclerotic apolipoprotein E-deficient rats., Vascul Pharmacol. 2022 Feb;142:106945. doi: 10.1016/j.vph.2021.106945. Epub 2021 Nov 18.

Autoimmune disease

Kalliokoski, S., Caja, S., Frias, R., Laurila, K., Koskinen, O., Niemela, O., . . . Lindfors, K. (2015), Injection of celiac disease patient sera or immunoglobulins to mice reproduces a condition mimicking early developing celiac disease., Journal of Molecular Medicine (Berlin, Germany), 93(1), 51-62. doi:10.1007/s00109-014-1204-8 [doi]

Cardiovascular

Wu Y, Zhao F, Sure VN, Ibrahim A, Yu C, Carr SM, Song P., Human ApoE2 Endows Stronger Contractility in Rat Cardiomyocytes Enhancing Heart Function, Cells. 2023 Jan 17;12(3):347. doi: 10.3390/cells12030347.

Corsetti G, Romano C, Pasini E, Scarabelli T, Chen-Scarabelli C, Dioguardi FS., Essential Amino Acids-Rich Diet Increases Cardiomyocytes Protection in Doxorubicin-Treated Mice, Nutrients. 2023 May 12;15(10):2287. doi: 10.3390/nu15102287.

Bruce, A. C., & Peirce, S. M. (2012)., Exogenous thrombin delivery promotes collateral capillary arterialization and tissue reperfusion in the murine spinotrapezius muscle ischemia model., Microcirculation (New York, N.Y.: 1994), 19(2), 143-154. doi:10.1111/j.1549-8719.2011.00138.x [doi]

Antonioni A, Dimauro I, Fantini C, Barone R, Macaluso F, Di Felice V, Caporossi D., ÎąB-crystallin response to a pro-oxidant non-cytotoxic environment in murine cardiac cells: An "in vitro" and "in vivo" study, Free Radic Biol Med. 2020 May 20;152:301-312. doi: 10.1016/j.freeradbiomed.2020.03.013. Epub 2020 Mar 26.

Schiviz, A., Magirr, D., Leidenmuhler, P., Schuster, M., Muchitsch, E. M., Hollriegl, W., & Subcommittee on Animal Models. (2014)., Influence of genetic background on bleeding phenotype in the tail-tip bleeding model and recommendations for standardization: Communication from the SSC of the ISTH., Journal of Thrombosis and Haemostasis : JTH, 12(11), 1940-1942. doi:10.1111/jth.12700 [doi]

Kolosowska N, Gotkiewicz M, Dhungana H, Giudice L, Giugno R, Box D, Huuskonen MT, Korhonen P, Scoyni F, Kanninen KM, YlĂ¤-Herttuala S, Turunen TA, Turunen MP, Koistinaho J, Malm T., Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation, J Neuroinflammation. 2020 Jun 19;17(1):194. doi: 10.1186/s12974-020-01870-w.

Stohr, R., Mavilio, M., Marino, A., Casagrande, V., Kappel, B., Mollmann, J., . . . Federici, M. (2015), ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice., Scientific Reports, 5, 9023. doi:10.1038/srep09023 [doi]

Bigelman E, Pasmanik-Chor M, Dassa B, Itkin M, Malitsky S, Dorot O, Pichinuk E, Kleinberg Y, Keren G, Entin-Meer M., Kynurenic acid, a key L-tryptophan-derived metabolite, protects the heart from an ischemic damage, PLoS One. 2023 Aug 24;18(8):e0275550. doi: 10.1371/journal.pone.0275550. eCollection 2023.

De Hoog, V. C., Timmers, L., Van Duijvenvoorde, A., De Jager, S. C., Van Middelaar, B. J., Smeets, M. B., . . . De Kleijn, D. P. (2014), Leucocyte expression of complement C5a receptors exacerbates infarct size after myocardial reperfusion injury, Cardiovascular Research, 103(4), 521-529. doi:10.1093/cvr/cvu153 [doi]

Itzhar A, Yosef G, Eilon-Ashkenazy M, Shmidov Y, Gil H, Lacham-Hartman S, Elyagon S, Etzion S, Bitton R, Cohen S, Etzion Y, Papo N., Potent inhibition of MMP-9 by a novel sustained-release platform attenuates left ventricular remodeling following myocardial infarction, J Control Release. 2023 Dec;364:246-260. doi: 10.1016/j.jconrel.2023.10.033. Epub 2023 Oct 31.

Turner, J. K., McAllister, M. M., Xu, J. L., & Tapping, R. I. (2008)., The resistance of BALB/cJ mice to yersinia pestis maps to the major histocompatibility complex of chromosome 17., Infection and Immunity, 76(9), 4092-4099. doi:10.1128/IAI.00488-08 [doi]

COVID-19

Tan T K, Rijal P, Rahikainen R, Keeble A H, Schimanski L, Hussain S, Harvey R, et al., A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses, bioRxiv 2020.08.31.275701; doi: https://doi.org/10.1101/2020.08.31.275701

Dinnon KH 3rd, Leist SR, Schäfer A, Edwards CE, Martinez DR, Montgomery SA, West A, Yount BL Jr, Hou YJ, Adams LE, Gully KL, Brown AJ, Huang E, Bryant MD, Choong IC, Glenn JS, Gralinski LE, Sheahan TP, Baric RS., A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures, Nature. 2020 Oct;586(7830):560-566. doi: 10.1038/s41586-020-2708-8. Epub 2020 Aug 27.

Gene therapy

Qiu M, Li G, Wang P, Li X, Lai F, Luo R, Liu B, Lin J., aarF domain containing kinase 5 gene promotes invasion and migration of lung cancer cells through ADCK5-SOX9-PTTG1 pathway, Exp Cell Res. 2020 Jul 1;392(1):112002. doi: 10.1016/j.yexcr.2020.112002. Epub 2020 Apr 8.

Lampe, J., Bossow, S., Weiland, T., Smirnow, I., Lehmann, R., Neubert, W., . . . Lauer, U. M. (2013)., An armed oncolytic measles vaccine virus eliminates human hepatoma cells independently of apoptosis., Gene Therapy, 20(11), 1033-1041. doi:10.1038/gt.2013.28 [doi]

Tiwari A, Iida M, Kosnopfel C, Abbariki M, Menegakis A, Fehrenbacher B, Maier J, Schaller M, Brucker SY, Wheeler DL, Harari PM, Rothbauer U, Schittek B, Zips D, Toulany M., Blocking Y-Box Binding Protein-1 through Simultaneous Targeting of PI3K and MAPK in Triple Negative Breast Cancers, Cancers (Basel). 2020 Sep 29;12(10):2795. doi: 10.3390/cancers12102795.

Feichtinger, G. A., Hacobian, A., Hofmann, A. T., Wassermann, K., Zimmermann, A., van Griensven, M., & Redl, H. (2014)., Constitutive and inducible co-expression systems for non-viral osteoinductive gene therapy., European Cells & Materials, 27, 166-84; discussion 184. doi:vol027a13 [pii]

McCarthy GA, Di Niro R, Finan JM, Jain A, Guo Y, Wyatt CR, Guimaraes AR, Waugh TA, Keith D, Morgan TK, Sears RC, Brody JR., Deletion of the mRNA stability factor ELAVL1 (HuR) in pancreatic cancer cells disrupts the tumor microenvironment integrity., NAR Cancer. 2023 Apr 19;5(2):zcad016. doi: 10.1093/narcan/zcad016. eCollection 2023 Jun.

Gentschev, I., Muller, M., Adelfinger, M., Weibel, S., Grummt, F., Zimmermann, M., . . . Szalay, A. A. (2011)., Efficient colonization and therapy of human hepatocellular carcinoma (HCC) using the oncolytic vaccinia virus strain GLV-1h68., PloS One, 6(7), e22069. doi:10.1371/journal.pone.0022069 [doi]

Arruabarrena-Aristorena A, Maag JLV, Kittane S, Cai Y, Karthaus WR, Ladewig E, Park J, Kannan S, Ferrando L, Cocco E, Ho SY, Tan DS, Sallaku M, Wu F, Acevedo B, Selenica P, Ross DS, Witkin M, Sawyers CL, Reis-Filho JS, Verma CS, Jauch R, Koche R, Baselga J, Razavi P, Toska E, Scaltriti M., FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer, Cancer Cell. 2020 Oct 12;38(4):534-550.e9. doi: 10.1016/j.ccell.2020.08.003. Epub 2020 Sep 3.

Yu, L., Liang, Y., Cao, X., Wang, X., Gao, H., Lin, S. Y., . . . Li, K. (2017), Identification of MYST3 as a novel epigenetic activator of ERalpha frequently amplified in breast cancer., Oncogene, 36(20), 2910-2918. doi:10.1038/onc.2016.433 [doi]

Unzu, C., Melero, I., Morales-Kastresana, A., Sampedro, A., Serrano-Mendioroz, I., Azpilikueta, A., . . . Fontanellas, A. (2014), Innate functions of immunoglobulin M lessen liver gene transfer with helper-dependent adenovirus, PloS One, 9(1), e85432. doi:10.1371/journal.pone.0085432 [doi]

Dowaidar, M., Abdelhamid, H. N., Hallbrink, M., Freimann, K., Kurrikoff, K., Zou, X., & Langel, U. (2017)., Magnetic nanoparticle assisted self-assembly of cell penetrating peptides-oligonucleotides complexes for gene delivery, Scientific Reports, 7(1), 9159-017-09803-z. doi:10.1038/s41598-017-09803-z [doi]

Dinami R, Pompili L, Petti E, Porru M, D'Angelo C, Di Vito S, Rizzo A, Campani V, De Rosa G, Bruna A, Serra V, Mano M, Giacca M, Leonetti C, Ciliberto G, Tarsounas M, Stoppacciaro A, Schoeftner S, Biroccio A., MiR-182-3p targets TRF2 and impairs tumor growth of triple-negative breast cancer., EMBO Mol Med. 2023 Jan 11;15(1):e16033. doi: 10.15252/emmm.202216033. Epub 2022 Nov 25.

Kim SS, Doherty C, Moghe M, Rait A, Pirollo KF, Harford JB, Chang EH., Nanomedicine-Based Gene Delivery for a Truncated Tumor Suppressor RB94 Promotes Lung Cancer Immunity, Cancers (Basel). 2022 Oct 18;14(20):5092. doi: 10.3390/cancers14205092.

Ady, J. W., Johnsen, C., Mojica, K., Heffner, J., Love, D., Pugalenthi, A., . . . Fong, Y. (2015)., Oncolytic gene therapy with recombinant vaccinia strain GLV-2b372 efficiently kills hepatocellular carcinoma., Surgery, 158(2), 331-338. doi:10.1016/j.surg.2015.03.044 [doi]

Veiman, K. L., Kunnapuu, K., Lehto, T., Kiisholts, K., Parn, K., Langel, U., & Kurrikoff, K. (2015)., PEG shielded MMP sensitive CPPs for efficient and tumor specific gene delivery in vivo., Journal of Controlled Release : Official Journal of the Controlled Release Society, 209, 238-247. doi:10.1016/j.jconrel.2015.04.038 [doi]

Croessmann, S., Wong, H. Y., Zabransky, D. J., Chu, D., Rosen, D. M., Cidado, J., . . . Park, B. H. (2017)., PIK3CA mutations and TP53 alterations cooperate to increase cancerous phenotypes and tumor heterogeneity., Breast Cancer Research and Treatment, 162(3), 451-464. doi:10.1007/s10549-017-4147-2 [doi]

Hollevoet, K., De Smidt, E., Geukens, N., & Declerck, P. (2018), Prolonged in vivo expression and anti-tumor response of DNA-based anti-HER2 antibodies, Oncotarget, 9(17), 13623-13636. doi:10.18632/oncotarget.24426 [doi]

Kaliberov, S. A., Kaliberova, L. N., Yan, H., Kapoor, V., & Hallahan, D. E. (2016)., Retargeted adenoviruses for radiation-guided gene delivery., Cancer Gene Therapy, 23(9), 303-314. doi:10.1038/cgt.2016.32 [doi]

Shapira, S., Shapira, A., Kazanov, D., Hevroni, G., Kraus, S., & Arber, N. (2017)., Selective eradication of cancer cells by delivery of adenovirus-based toxins., Oncotarget, 8(24), 38581-38591. doi:10.18632/oncotarget.16934 [doi]

Anders, N. M., Liu, J., Wanjiku, T., Giovinazzo, H., Zhou, J., Vaghasia, A., . . . Rudek, M. A. (2016)., Simultaneous quantitative determination of 5-aza-2'-deoxycytidine genomic incorporation and DNA demethylation by liquid chromatography tandem mass spectrometry as exposure-response measures of nucleoside analog DNA methyltransferase inhibitors, Journal of Chromatography.B, Analytical Technologies in the Biomedical and Life Sciences, 1022, 38-45. doi:S1570-0232(16)30178-7 [pii]

Feichtinger, G. A., Hofmann, A. T., Slezak, P., Schuetzenberger, S., Kaipel, M., Schwartz, E., . . . Redl, H. (2014)., Sonoporation increases therapeutic efficacy of inducible and constitutive BMP2/7 in vivo gene delivery., Human Gene Therapy Methods, 25(1), 57-71. doi:10.1089/hgtb.2013.113 [doi]

Abel, T., El Filali, E., Waern, J., Schneider, I. C., Yuan, Q., Munch, R. C., . . . Buchholz, C. J. (2013)., Specific gene delivery to liver sinusoidal and artery endothelial cells, Blood, 122(12), 2030-2038. doi:10.1182/blood-2012-11-468579 [doi]

Hou R, Yu Y, Sluter MN, Li L, Hao J, Fang J, Yang J, Jiang J., Targeting EP2 receptor with multifaceted mechanisms for high-risk neuroblastoma, Cell Rep. 2022 Jun 21;39(12):111000. doi: 10.1016/j.celrep.2022.111000.

Chatterjee S, Naidu GS, Hazan-Halevy I, Grobe H, Ezra A, Sharma P, Goldsmith M, Ramishetti S, Sprinzak D, Zaidel-Bar R, Peer D., Therapeutic gene silencing of CKAP5 leads to lethality in genetically unstable cancer cells., Sci Adv. 2023 Apr 5;9(14):eade4800. doi: 10.1126/sciadv.ade4800. Epub 2023 Apr 5.

Presutti, D., Ceccarelli, M., Micheli, L., Papoff, G., Santini, S., Samperna, S., . . . Tirone, F. (2018)., Tis21-gene therapy inhibits medulloblastoma growth in a murine allograft model., PloS One, 13(3), e0194206. doi:10.1371/journal.pone.0194206 [doi]

Nomikou, N., Feichtinger, G. A., Saha, S., Nuernberger, S., Heimel, P., Redl, H., & McHale, A. P. (2018)., Ultrasound-responsive gene-activated matrices for osteogenic gene therapy using matrix-assisted sonoporation., Journal of Tissue Engineering and Regenerative Medicine, 12(1), e250-e260. doi:10.1002/term.2406 [doi]

General studies

Waugh CM, Mousavizadeh R, Lee J, Screen HRC, Scott A., Mild hypercholesterolemia impacts achilles sub-tendon mechanical properties in young rats, BMC Musculoskelet Disord. 2023 Apr 12;24(1):282. doi: 10.1186/s12891-023-06375-0.

Choi YH, Zhang C, Liu Z, Tu MJ, Yu AX, Yu AM., A Novel Integrated Pharmacokinetic-Pharmacodynamic Model to Evaluate Combination Therapy and Determine In Vivo Synergism, J Pharmacol Exp Ther. 2021 Jun;377(3):305-315. doi: 10.1124/jpet.121.000584. Epub 2021 Mar 12.

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Crum RJ, Capella-MonsonÃs H, Chang J, Dewey MJ, Kolich BD, Hall KT, El-Mossier SO, Nascari DG, Hussey GS, Badylak SF., Biocompatibility and biodistribution of matrix-bound nanovesicles in vitro and in vivo., Acta Biomater. 2023 Jan 1;155:113-122. doi: 10.1016/j.actbio.2022.11.026. Epub 2022 Nov 22.

Puigdelloses M, Garcia-Moure M, Labiano S, Laspidea V, Gonzalez-Huarriz M, Zalacain M, Marrodan L, Martinez-Velez N, De la Nava D, Ausejo I, Hervás-Stubbs S, Herrador G, Chen Z, Hambardzumyan D, Patino Garcia A, Jiang H, Gomez-Manzano C, Fueyo J, Gállego Pérez-Larraya J, Alonso M., CD137 and PD-L1 targeting with immunovirotherapy induces a potent and durable antitumor immune response in glioblastoma models, J Immunother Cancer. 2021 Jul;9(7):e002644. doi: 10.1136/jitc-2021-002644.

Wedekind MF, Miller KE, Chen CY, Wang PY, Hutzen BJ, Currier MA, Nartker B, Roberts RD, Boon L, Conner J, LaHaye S, Kelly BJ, Gordon D, White P, Mardis ER, Cripe TP., Endogenous retrovirus envelope as a tumor-associated immunotherapeutic target in murine osteosarcoma, iScience. 2021 Jun 19;24(7):102759. doi: 10.1016/j.isci.2021.102759. eCollection 2021 Jul 23.

Verma B, Wesa A., Establishment of Humanized Mice from Peripheral Blood Mononuclear Cells or Cord Blood CD34+ Hematopoietic Stem Cells for Immune-Oncology Studies Evaluating New Therapeutic Agents, Curr Protoc Pharmacol. 2020 Jun;89(1):e77. doi: 10.1002/cpph.77.

Alvero AB, Fox A, Madina BR, Krady MM, Gogoi R, Chehade H, Nakaar V, Almassian B, Yarovinsky TO, Rutherford T, Mor G., Immune modulation of innate and adaptive responses restores immune surveillance and establishes anti-tumor immunological memory., Cancer Immunol Res. 2023 Dec 11. doi: 10.1158/2326-6066.CIR-23-0127. [Epub ahead of print]

Ahmed MSU, Lord BD, Adu Addai B, Singhal SK, Gardner K, Salam AB, Ghebremedhin A, White J, Mahmud I, Martini R, Bedi D, Lin H, Jones JD, Karanam B, Dean-Colomb W, Grizzle W, Wang H, Davis M, Yates CC., Immune Profile of Exosomes in African American Breast Cancer Patients Is Mediated by Kaiso/THBS1/CD47 Signaling., Cancers (Basel). 2023 Apr 13;15(8). pii: 2282. doi: 10.3390/cancers15082282.

Li M, Wei W, Barnhart TE, Jiang D, Cao T, Fan K, Engle JW, Liu J, Chen W, Cai W., ImmunoPET/NIRF/Cerenkov multimodality imaging of ICAM-1 in pancreatic ductal adenocarcinoma, Eur J Nucl Med Mol Imaging. 2021 Aug;48(9):2737-2748. doi: 10.1007/s00259-021-05216-3. Epub 2021 Feb 3.

Landau S, Newman A, Edri S, Michael I, Ben-Shaul S, Shandalov Y, Ben-Arye T, Kaur P, Zheng MH, Levenberg S., Investigating lymphangiogenesis in vitro and in vivo using engineered human lymphatic vessel networks, Proc Natl Acad Sci U S A. 2021 Aug 3;118(31):e2101931118. doi: 10.1073/pnas.2101931118.

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Nair, Vidhya R; Malladi, Srinivas;, Mouse Models to Study Natural Killer Cell-Mediated Immunosurveillance and Metastatic Latency., Methods in molecular biology (Clifton, N.J.) Vol.1884, 2019

Hedberg J, Studebaker A, Smith L, Chen CY, Westfall JJ, Cam M, Gross A, Hernandez-Aguirre I, Martin A, Kim D, Dhital R, Kim Y, Roberts RD, Cripe TP, Mardis ER, Cassady KA, Leonard J, Miller KE., Oncolytic virus-driven immune remodeling revealed in mouse medulloblastomas at single cell resolution., Mol Ther Oncolytics. 2023 Jul 19;30:39-55. doi: 10.1016/j.omto.2023.07.006. eCollection 2023 Sep 21.

Jacobson, O., Li, Q., Chen, H., Niu, G., Kiesewetter, D. O., Xu, L., . . . Chen, X. (2017)., PET-guided evaluation and optimization of internalized antibody-drug conjugates targeting erythropoietin-producing hepatoma A2 receptor., Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, 58(11), 1838-1844. doi:10.2967/jnumed.117.192245 [doi]

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Hsiao, H. C., Fan, X., Jordan, R. E., Zhang, N., & An, Z. (2018)., Proteolytic single hinge cleavage of pertuzumab impairs its fc effector function and antitumor activity in vitro and in vivo, Breast Cancer Research : BCR, 20(1), 43-018-0972-4. doi:10.1186/s13058-018-0972-4 [doi]

Hutzen, B., Chen, C. Y., Wang, P. Y., Sprague, L., Swain, H. M., Love, J., . . . Cripe, T. P. (2017)., TGF-beta inhibition improves oncolytic herpes viroimmunotherapy in murine models of rhabdomyosarcoma, Molecular Therapy Oncolytics, 7, 17-26. doi:10.1016/j.omto.2017.09.001 [doi]

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Maitra, R., Augustine, T., Dayan, Y., Chandy, C., Coffey, M., & Goel, S. (2017)., Toll like receptor 3 as an immunotherapeutic target for KRAS mutated colorectal cancer, Oncotarget, 8(21), 35138-35153. doi:10.18632/oncotarget.16812 [doi]

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Neuroscience

Berenji Ardestani, Simin; Matchkov, Vladimir V; Eftedal, Ingrid; Pedersen, Michael;, A Single Simulated Heliox Dive Modifies Endothelial Function in the Vascular Wall of ApoE Knockout Male Rats More Than Females., Frontiers in physiology Vol.10, 2019

Phillips, Evan H; Chang, Mandy S; Gorman, Sydney; Qureshi, Hamna J; Ejendal, Karin F K; Kinzer-Ursem, Tamara L; Blaize, A Nicole; Goergen, Craig J;, Angiotensin II Infusion Does Not Cause Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Rats., Journal of vascular research Vol.55, 2018

Cornelissen, Anne; Simsekyilmaz, Sakine; Liehn, Elisa; Rusu, Mihaela; Schaaps, Nicole; Afify, Mamdouh; Florescu, Roberta; Almalla, Mohammad; Borinski, Mauricio; Vogt, Felix;, Apolipoprotein E deficient rats generated via zinc-finger nucleases exhibit pronounced in-stent restenosis., Scientific reports Vol.9, 2019

Rune, Ida; Rolin, Bidda; Lykkesfeldt, Jens; Nielsen, Dennis Sandris; Krych, Lukasz; Kanter, Jenny E; Bornfeldt, Karin E; Kihl, Pernille; Buschard, Karsten; Josefsen, Knud; Fels, Johannes Josef; Mortensen, Alan; Christoffersen, Berit; Kirk, Rikke Kaae; Hansen, Axel Kornerup;, Long-term Western diet fed apolipoprotein E-deficient rats exhibit only modest early atherosclerotic characteristics., Scientific reports Vol.8, 2018

Hohl, Mathias; Linz, Dominik; Fries, Peter; MĂźller, Andreas; Stroeder, Jonas; Urban, Daniel; Speer, Thimoteus; Geisel, JĂźrgen; Hummel, BjĂśrn; Laufs, Ulrich; Schirmer, Stephan H; BĂśhm, Michael; Mahfoud, Felix;, Modulation of the sympathetic nervous system by renal denervation prevents reduction of aortic distensibility in atherosclerosis prone ApoE-deficient rats., Journal of translational medicine Vol.14, 2016

Nguyen TD, Hållenius FF, Lin X, Nyman M, Prykhodko O., Monobutyrin and Monovalerin Affect Brain Short-Chain Fatty Acid Profiles and Tight-Junction Protein Expression in ApoE-Knockout Rats Fed High-Fat Diets, Nutrients. 2020 Apr 24;12(4):1202. doi: 10.3390/nu12041202.

Obesity

Pohjanvirta, R., Karppinen, I., Galbán-Velázquez, S., Esteban, J., Hĺkansson, H., Sankari, S., & Lindén, J., Effects of a high-fat diet and global aryl hydrocarbon receptor deficiency on energy balance and liver retinoid status in male Sprague-Dawley rats, The Journal of Nutritional Biochemistry 95 (2021): 108762.

Oncology

Siddique AB, Kilgore PCSR, Tajmim A, Singh SS, Meyer SA, Jois SD, Cvek U, Trutschl M, Sayed KAE., (-)-Oleocanthal as a Dual c-MET-COX2 Inhibitor for the Control of Lung Cancer, Nutrients. 2020 Jun 11;12(6):1749. doi: 10.3390/nu12061749.

Jiménez-Mora E, Gallego B, Díaz-Gago S, Lasa M, Baquero P, Chiloeches A., (V600E)BRAF Inhibition Induces Cytoprotective Autophagy through AMPK in Thyroid Cancer Cells, Int J Mol Sci. 2021 Jun 3;22(11):6033. doi: 10.3390/ijms22116033.

Masoodi, K. Z., Ramos Garcia, R., Pascal, L. E., Wang, Y., Ma, H. M., O'Malley, K., . . . Wang, Z. (2013)., 5alpha-reductase inhibition suppresses testosterone-induced initial regrowth of regressed xenograft prostate tumors in animal models., Endocrinology, 154(7), 2296-2307. doi:10.1210/en.2012-2077 [doi]

Yang, Hailing; Shu, Zhang; Jiang, Yongying; Mao, Weiqun; Pang, Lan; Redwood, Abena; Jeter-Jones, Sabrina L; Jennings, Nicholas B; Ornelas, Argentina; Zhou, Jinhua; Rodriguez-Aguayo, Cristian; Bartholomeusz, Geoffrey; Iles, LaKesla R; Zacharias, Niki M; Millward, Steven W; Lopez-Berestein, Gabriel; Le, Xiao-Feng; Ahmed, Ahmed A; Piwnica-Worms, Helen; Sood, Anil K; Bast, Robert C; Lu, Zhen, 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-2 Regulates TP53-Dependent Paclitaxel Sensitivity in Ovarian and Breast Cancers, Clinical cancer research : an official journal of the American Association for Cancer Research Vol.25, 2019

Marayati R, Bownes LV, Stafman LL, Williams AP, Quinn CH, Atigadda V, Aye JM, Stewart JE, Yoon KJ, Beierle EA., 9-cis-UAB30, a novel rexinoid agonist, decreases tumorigenicity and cancer cell stemness of human neuroblastoma patient-derived xenografts, Transl Oncol. 2021 Jan;14(1):100893. doi: 10.1016/j.tranon.2020.100893. Epub 2020 Sep 30.

Deng, Y., Wang, Z., Zhang, F., Qiao, M., Yan, Z., Wei, Q., . . . Zhang, J. (2016), A blockade of IGF signaling sensitizes human ovarian cancer cells to the anthelmintic niclosamide-induced anti-proliferative and anticancer activities, Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 39(3), 871-888. doi:10.1159/000447797 [doi]

Kuznik NC, Solozobova V, Lee II, Jung N, Yang L, Nienhaus K, Ntim EA, Rottenberg JT, Muhle-Goll C, Kumar AR, Peravali R, Gräßle S, Gourain V, Deville C, Cato L, Neeb A, Dilger M, Cramer von Clausbruch CA, Weiss C, Kieffer B, Nienhaus GU, Brown M, Bräse S, Cato ACB., A chemical probe for BAG1 targets androgen receptor-positive prostate cancer through oxidative stress signaling pathway, iScience. 2022 Mar 31;25(5):104175. doi: 10.1016/j.isci.2022.104175. eCollection 2022 May 20.

Zhao Y, Wang C, Goel A., A combined treatment with melatonin and andrographis promotes autophagy and anticancer activity in colorectal cancer, Carcinogenesis. 2022 Apr 25;43(3):217-230. doi: 10.1093/carcin/bgac008.

Luderer, M. J., Muz, B., de la Puente, P., Chavalmane, S., Kapoor, V., Marcelo, R., . . . Azab, A. K. (2016), A hypoxia-targeted boron neutron capture therapy agent for the treatment of glioma., Pharmaceutical Research, 33(10), 2530-2539. doi:10.1007/s11095-016-1977-2 [doi]

Tian Q, Zhang P, Wang Y, Si Y, Yin D, Weber CR, Fishel ML, Pollok KE, Qiu B, Xiao F, Chong AS., A novel triptolide analog downregulates NF-kB and induces mitochondrial apoptosis pathways in human pancreatic cancer., Elife. 2023 Oct 25;12. pii: e85862. doi: 10.7554/eLife.85862. [Epub ahead of print]

Shivange G, Mondal T, Lyerly E, Bhatnagar S, Landen CN, Reddy S, Kim J, Doan B, Riddle P, Tushir-Singh J., A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors, Cell Rep. 2021 Nov 2;37(5):109953. doi: 10.1016/j.celrep.2021.109953.

Hight, M. R., Cheung, Y. Y., Nickels, M. L., Dawson, E. S., Zhao, P., Saleh, S., . . . Manning, H. C. (2014)., A peptide-based positron emission tomography probe for in vivo detection of caspase activity in apoptotic cells., Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 20(8), 2126-2135. doi:10.1158/1078-0432.CCR-13-2444 [doi]

Dey, J., Kerwin, W. S., Grenley, M. O., Casalini, J. R., Tretyak, I., Ditzler, S. H., . . . Klinghoffer, R. A. (2016), A platform for rapid, quantitative assessment of multiple drug combinations simultaneously in solid tumors in vivo., PloS One, 11(6), e0158617. doi:10.1371/journal.pone.0158617 [doi]

Green, D. J., Orgun, N. N., Jones, J. C., Hylarides, M. D., Pagel, J. M., Hamlin, D. K., . . . Press, O. W. (2014), A preclinical model of CD38-pretargeted radioimmunotherapy for plasma cell malignancies., Cancer Research, 74(4), 1179-1189. doi:10.1158/0008-5472.CAN-13-1589 [doi]

Yang, Lu; Li, Yun; Bhattacharya, Arup; Zhang, Yuesheng;, A recombinant human protein targeting HER2 overcomes drug resistance in HER2-positive breast cancer., Science translational medicine Vol.11, 2019

Neiveyans, Madeline; Melhem, Rana; Arnoult, Christophe; Bourquard, Thomas; Jarlier, Marta; Busson, Muriel; Laroche, Adrien; Cerutti, Martine; PugniĂ¨re, Martine; Ternant, David; Gaborit, NadĂ¨ge; ChardĂ¨s, Thierry; Poupon, Anne; Gouilleux-Gruart, ValĂŠrie; PĂ¨legrin, Andre; Poul, Marie-Alix;, A recycling anti-transferrin receptor-1 monoclonal antibody as an efficient therapy for erythroleukemia through target up-regulation and antibody-dependent cytotoxic effector functions, mAbs Vol.11, 2019

Santich BH, Cheal SM, Ahmed M, McDevitt MR, Ouerfelli O, Yang G, Veach DR, Fung EK, Patel M, Burnes Vargas D, Malik AA, Guo HF, Zanzonico PB, Monette S, Michel AO, Rudin CM, Larson SM, Cheung NK., A Self-Assembling and Disassembling (SADA) Bispecific Antibody (BsAb) Platform for Curative Two-step Pretargeted Radioimmunotherapy, Clin Cancer Res. 2020 Sep 21. doi: 10.1158/1078-0432.CCR-20-2150. Online ahead of print.

Santich BH, Cheal SM, Ahmed M, McDevitt MR, Ouerfelli O, Yang G, Veach DR, Fung EK, Patel M, Burnes Vargas D, Malik AA, Guo HF, Zanzonico PB, Monette S, Michel AO, Rudin CM, Larson SM, Cheung NK., A Self-Assembling and Disassembling (SADA) Bispecific Antibody (BsAb) Platform for Curative Two-step Pretargeted Radioimmunotherapy, Clin Cancer Res. 2021 Jan 15;27(2):532-541. doi: 10.1158/1078-0432.CCR-20-2150. Epub 2020 Sep 21.

Pattarawat P, Hunt JT, Poloway J, Archibald CJ, Wang HR., A triple combination gemcitabine?+?romidepsin?+?cisplatin to effectively control triple-negative breast cancer tumor development, recurrence, and metastasis, Cancer Chemother Pharmacol. 2021 Sep;88(3):415-425. doi: 10.1007/s00280-021-04298-y. Epub 2021 May 27.

Roy, L. D., Dillon, L. M., Zhou, R., Moore, L. J., Livasy, C., El-Khoury, J. M., . . . Mukherjee, P. (2017)., A tumor specific antibody to aid breast cancer screening in women with dense breast tissue., Genes & Cancer, 8(3-4), 536-549. doi:10.18632/genesandcancer.134 [doi]

Kim, S. S., Rait, A., Kim, E., Pirollo, K. F., & Chang, E. H. (2015)., A tumor-targeting p53 nanodelivery system limits chemoresistance to temozolomide prolonging survival in a mouse model of glioblastoma multiforme., Nanomedicine : Nanotechnology, Biology, and Medicine, 11(2), 301-311. doi:10.1016/j.nano.2014.09.005 [doi]

Formisano, Luigi; Lu, Yao; Servetto, Alberto; Hanker, Ariella B; Jansen, Valerie M; Bauer, Joshua A; Sudhan, Dhivya R; Guerrero-Zotano, Angel L; Croessmann, Sarah; Guo, Yan; Ericsson, Paula Gonzalez; Lee, Kyung-Min; Nixon, Mellissa J; Schwarz, Luis J; Sanders, Melinda E; Dugger, Teresa C; Cruz, Marcelo Rocha; Behdad, Amir; Cristofanilli, Massimo; Bardia, Aditya; OShaughnessy, Joyce; Nagy, Rebecca J; Lanman, Richard B; Solovieff, Nadia; He, Wei; Miller, Michelle; Su, Fei; Shyr, Yu; Mayer, Ingrid A; Balko, Justin M; Arteaga, Carlos L;, Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer., Nature communications Vol.10, 2019

Li M, Li J, Guo X, Pan H, Zhou Q., Absence of HTATIP2 Expression in A549 Lung Adenocarcinoma Cells Promotes Tumor Plasticity in Response to Hypoxic Stress, Cancers (Basel). 2020 Jun 11;12(6):1538. doi: 10.3390/cancers12061538.

Tansi, F. L., Ruger, R., Bohm, C., Steiniger, F., Kontermann, R. E., Teichgraeber, U. K., . . . Hilger, I. (2017)., Activatable bispecific liposomes bearing fibroblast activation protein directed single chain fragment/Trastuzumab deliver encapsulated cargo into the nuclei of tumor cells and the tumor microenvironment simultaneously., Acta Biomaterialia, 54, 281-293. doi:S1742-7061(17)30203-9 [pii]

Young, N. R., Soneru, C., Liu, J., Grushko, T. A., Hardeman, A., Olopade, O. I., . . . Cohen, E. E. (2015)., Afatinib efficacy against squamous cell carcinoma of the head and neck cell lines in vitro and in vivo., Targeted Oncology, 10(4), 501-508. doi:10.1007/s11523-014-0353-6 [doi]

Ziegler, J., Bastian, A., Lerner, M., Bailey-Downs, L., Saunders, D., Smith, N., . . . Towner, R. A. (2017)., AG488 as a therapy against gliomas., Oncotarget, 8(42), 71833-71844. doi:10.18632/oncotarget.18284 [doi]

Gomes AP, Ilter D, Low V, Endress JE, Fernández-García J, Rosenzweig A, Schild T, Broekaert D, Ahmed A, Planque M, Elia I, Han J, Kinzig C, Mullarky E, Mutvei AP, Asara J, de Cabo R, Cantley LC, Dephoure N, Fendt SM, Blenis J., Age-induced accumulation of methylmalonic acid promotes tumour progression, Nature. 2020 Sep;585(7824):283-287. doi: 10.1038/s41586-020-2630-0. Epub 2020 Aug 19.

Dunn S, Eberlein C, Yu J, Gris-Oliver A, Ong SH, Yelland U, Cureton N, Staniszewska A, McEwen R, Fox M, Pilling J, Hopcroft P, Coker EA, Jaaks P, Garnett MJ, Isherwood B, Serra V, Davies BR, Barry ST, Lynch JT, Yusa K., AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kβ/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors, Oncogene. 2022 Nov;41(46):5046-5060. doi: 10.1038/s41388-022-02482-9. Epub 2022 Oct 14.

Sun Y, Meyers BA, Czako B, Leonard P, Mseeh F, Harris AL, Wu Q, Johnson S, Parker CA, Cross JB, Di Francesco ME, Bivona BJ, Bristow CA, Burke JP, Carrillo CC, Carroll CL, Chang Q, Feng N, Gao G, Gera S, Giuliani V, Huang JK, Jiang Y, Kang Z, Kovacs JJ, Liu CY, Lopez AM, Ma X, Mandal PK, McAfoos T, Miller MA, Mullinax RA, Peoples M, Ramamoorthy V, Seth S, Spencer ND, Suzuki E, Williams CC, Yu SS, Zuniga AM, Draetta GF, Marszalek JR, Heffernan TP, Kohl NE, Jones P., Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib, Cancer Res. 2020 Nov 1;80(21):4840-4853. doi: 10.1158/0008-5472.CAN-20-1634. Epub 2020 Sep 14.

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Miles, L. A., Burga, L. N., Gardner, E. E., Bostina, M., Poirier, J. T., & Rudin, C. M. (2017)., Anthrax toxin receptor 1 is the cellular receptor for seneca valley virus., The Journal of Clinical Investigation, 127(8), 2957-2967. doi:10.1172/JCI93472 [doi]

Moody, G., Belmontes, B., Masterman, S., Wang, W., King, C., Murawsky, C., . . . Beltran, P. J. (2016)., Antibody-mediated neutralization of autocrine Gas6 inhibits the growth of pancreatic ductal adenocarcinoma tumors in vivo, International Journal of Cancer, 139(6), 1340-1349. doi:10.1002/ijc.30180 [doi]

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ICR (CD-1®) outbred mice

ICR (CD-1®) Mice: The Versatile Workhorses of Biomedical Research