 
    
    Mdr1a-Bcrp knockout rats
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          ADMET
        
      ADMET
              Fuchs H, Kishimoto W, Gansser D, Tanswell P, Ishiguro N., 
              Brain penetration of WEB 2086 (Apafant) and dantrolene in Mdr1a (P-glycoprotein) and Bcrp knockout rats., 
              Drug Metab Dispos. 2014 Oct;42(10):1761-5. doi: 10.1124/dmd.114.058545.Epub 2014 Jul 22.
            
            
            
            
              Huang L, Li X, Roberts J, Janosky B, Lin MH., 
              Differential role of P-glycoprotein and breast cancer resistance protein in drug distribution into brain, CSF and peripheral nerve tissues in rats., 
              Xenobiotica. 2015;45(6):547-55.  doi: 10.3109/00498254.2014.997324.
            
            
            
            
              Miyake T., 
              Estimating Efflux Transporter-Mediated Disposition of Molecules beyond the Rule of Five (bRo5) Using Transporter Gene Knockout Rats., 
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              Sato S, Tohyama K, Kosugi Y., 
              Investigation of MDR1-overexpressing cell lines to derive a quantitative prediction approach for brain disposition using in vitro efflux activities., 
              Eur J Pharm Sci. 2020 Jan 15;142:105119.
            
            
            
            
              Ganguly S, Panetta JC, Roberts JK, Schuetz EG., 
              Ketamine Pharmacokinetics and Pharmacodynamics Are Altered by P-Glycoprotein and Breast Cancer Resistance Protein Efflux Transporters in Mice., 
              Drug Metab Dispos. 2018 Jul;46(7):1014-1022. doi: 10.1124/dmd.117.078360. Epub 2018 Apr 19.
            
            
           
  
