C57BL/6 Diet-induced obesity (DIO) mice

• Coat: Black
• Haplotype: H-2b
• Litter Average: 5.0
• Obese phenotype
• Glucose intolerance
• Insulin intolerance
• Elevated blood glucose
• Dyslipidemia
• Liver steatosis
• High preference for alcohol
• Microphthalmia
• Incidence of hydrocephalous
• The C57BL/6N subline carries a retinal degeneration 8 mutation (rd8)
• The C57BL/6NHsd subline does not carry the Nnt (nicotinamide nucleotice transhydrogenase) gene deletion

Origin:
C57BL/6NHsd; Derived from a nucleus colony obtained from the National Institutes of Health, Bethesda, Maryland.

Diet and Husbandry:
Our rodent models are raised and maintained on the following diet, bedding, and enrichment products:

• Diet: Teklad Global Rodent Diet – (DIO control mice only)
• Diet: Research Diet D12492 (60% HFD) – (DIO mice only)
• Bedding: Teklad Contact Bedding (U.S. only)
• Enrichment: Teklad Enrichment Products (U.S. only)

Model Support Services:
Inotiv offers related model support services to deliver research-ready models to your facility:

• Surgical Services
• Preconditioning Services
• Contract Breeding Services
• Biospecimen Services

Health Monitoring Report Update
Inotiv is standardizing global health monitoring to deliver consistent, rigorous surveillance. Updated reports featuring our revised testing frequencies and agents will begin with the September 2026 cycle with reports becoming available between mid-September and early October.

Historical data for the previous 18 months will remain available under the Technical Resources tab. For details on monitored agents and testing frequencies, visit our Health Monitoring Reports page.  Please contact us if you have any questions or concerns.

• United States - 208A - Frederick, MD

Available regions:

Order code: 044 - US

• C57BL/6 Diet-induced obesity (DIO) model sheet
• Model information sheet - EU
• Fighting mice data sheet