Mdr1a-1b knockout rats

• Background strain: Sprague Dawley
• Mdr1a (Abcba1) and Mdr1b (Abc1b) have both been knocked out as a large deletion

Availability: Live colony
Zygosity genotype: Homozygous

P-glycoprotein plays a critical role in efflux for both brain and liver. Homozygous null Mdr1a rats display increased exposure to CNS drugs in the brain, as well as increased bioavailability in the plasma for P-gp-specific substrates.

MDR1 encodes for P-glycoprotein and is a membrane-bound drug transporter expressed in the brain and intestine. It effectively blocks drugs from crossing the blood-brain barrier. P-gp can confer multiple drug resistance to tumor cells. Absence of P-gp creates a functional deficiency in the blood-brain barrier and results in elevated drug levels in many tissues, making this a useful model for efflux assay, efficacy, formulation, tissue distribution, studying neurotoxicology and chemotherapeutic agents.

Origin:

The Mdr1a-1b KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.

Diet and Husbandry:

Inotiv’s iCare^TM Program focuses on creating industry awareness and continuing the highest-quality nutrition, bedding, and meaningful environmental enrichment for a wide range of laboratory animal species. Our iCare program supports the same standards of care we provide for our animal models while offering customers a convenient, single source for these essential products for their research facilities.

Diet:

The ideal lab animal diet is the 2018 Teklad Global 18% Protein Rodent Diet (Irradiated or Autoclavable).

Bedding:

The preferred bedding product is Teklad Corncob Bedding.

Enrichment:

The environmental enrichment products that are provided in a rotation include Teklad Diamond Twists, as well as Sizzle-Nest, Shelters, Cocoons, and Paper Wool from our welfareplus+^® line of enrichment products.

Model Support Services:
Inotiv offers related model support services to deliver research-ready models to your facility:

• Surgical Services
• Preconditioning Services
• Aging Services
• Contract Breeding Services
• Biospecimen Services

Health Monitoring Report Update
Inotiv is standardizing global health monitoring to deliver consistent, rigorous surveillance. Updated reports featuring our revised testing frequencies and agents will begin with the September 2026 cycle with reports becoming available between mid-September and early October.

Historical data for the previous 18 months will remain available under the Technical Resources tab. For details on monitored agents and testing frequencies, visit our Health Monitoring Reports page.  Please contact us if you have any questions or concerns.

• United States - Building 410 Denver, PA

Available regions:

For pricing information, please contact us using the phone number above.

• iCare Program: Continuity of Care — US
• Model information sheet

Archived Health Monitoring Reports

• United States - Building 410 Denver, PA