Pulmonary Disease & Injury
An unmet need for effective treatments for pulmonary diseases represents a large burden on medical practice. The initiation and progression processes are not fully understood for many pulmonary diseases. The prevalence of Obstructive Lung Disease (COPD, Airway Hyper-Reactivity), Restrictive Lung Disease (Pulmonary Fibrosis) and Pulmonary Arterial Hypertension (PAH) is increasing every year due to a multitude of factors as well as increased precision in diagnosis. PBI is a leader in pulmonary therapeutic development, offering an expanding portfolio of pulmonary disease models ranging from acute injury to fibrotic disease. In accordance with our integrative platform, concomitant right side heart remodeling and pulmonary hemodynamics are regularly evaluated to provide interpretable data to best represent human disease.
Pulmonary Fibrosis
| Model | Species | Top Tier Data |
|---|---|---|
| Bleomycin | Rat & Mouse | • Direct pulmonary mechanics (FlexiVent) • Indirect pulmonary mechanics (whole body plethysmography) • Blood Gas • Lung Histology (Fibrosis) • Lung Profibrotic & Proinflammatory mRNA expression • Right Ventricle mRNA Expression |
Pulmonary Arterial Hypertension
| Model | Species | Top Tier Data |
|---|---|---|
| Monocrotaline | Rat | • Direct pulmonary artery hemodynamics • Direct pulmonary mechanics (FlexiVent) • Direct arterial hemodynamic • Blood Gas • Lung Histology (Fibrosis) • Lung Profibrotic & Proinflammatory mRNA Expression • Right Ventricle mRNA Expression |
Acute Lung Injury
| Model | Species | Top Tier Data |
|---|---|---|
| Lipopolysaccharide (LPS) | Rat & Mouse | • Bronchoalveolar Lavage Fluid (BALF) cell differential, neutrophils & cytokines • Direct Pulmonary mechanics (FlexiVent) |
| Bleomycin | Rat |
Airway Hyper-Responsiveness (AHR) / Asthma
| Model | Species | Top Tier Data |
|---|---|---|
| House Dust Mite (HDM) | Mouse | • Direct pulmonary Mechanics (Methacholine Challenge – FlexiVent) • Bronchoalveolar Lavage Fluid (BALF) cell differential, neutrophils & cytokines • Lung Histology (Goblet Cell Hyperplasia / Muscin Staining) • Serum IgE |
| Ovalbumin (OVA) | Rat & Mouse |
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