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Integrated CVRM Research Resources
Explore cardiovascular, renal and metabolic (CVRM) research resources supporting translational drug discovery and development.
One Disease Area. Multiple Biological Drivers.
Cardiovascular, renal and metabolic diseases are deeply interconnected, with hypertension, renal dysfunction, metabolic imbalance and RAAS dysregulation all influencing disease progression and therapeutic response. These biological links make translational study design and model selection especially important in CVRM research.
Inotiv supports integrated CVRM research with preclinical solutions and scientific resources designed to help teams generate meaningful, decision-ready data from discovery through development.
Explore our CVRM research capabilities
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Featured CVRM Research Resources
Explore translational cardiovascular, renal and metabolic research resources designed to support integrated preclinical drug discovery across CVRM disease areas.
Navigating Cardiovascular Complexity from Discovery Through Development
This brief overview highlights how Inotiv supports translational cardiovascular research through integrated preclinical solutions designed to generate meaningful, decision-ready data.
Watch our 2-minute cardiovascular overview video!
Expert-Led CVRM Webinars
Access on-demand webinars covering translational cardiovascular research, metabolic disease models, renal dysfunction and integrated preclinical strategies across CVRM research.
Hypertension, A Driver of Cardiovascular and Renal Disease
Selecting appropriate preclinical models is critical for understanding how hypertension contributes to cardiovascular and renal disease progression. Hear experts present translational animal models used to study these complex disease systems.
Watch the Hypertension On-Demand Webinar!
CVRM Guides and Overviews
Download educational guides exploring translational models, disease progression, and clinically relevant endpoints in CVRM research.
Cardiorenal Animal Models for Hypertension
A practical, accessible guide that explains how hypertension drives cardiovascular and renal disease and introduces commonly used translational animal models.
Download the Cardiorenal Guide!
Scientific Posters in CVRM Research
Explore scientific posters highlighting translational animal models, disease mechanisms, and preclinical research capabilities across CVRM disease areas.
Obese ZSF1 Rat Model
Characterization of the Obese ZSF1 Rat as a Translational Model of Human Cardiometabolic Syndrome and the Cardioprotective Effects of Lisinopril
View the ZSF1 Rat Scientific Poster
Diet-Induced Obesity (DIO) Mouse Model
Characterization of Incretin-Based Therapies for Weight Loss in Inotiv Mouse Model of Diet Induced Obesity
View the DIO Mouse Scientific Poster
Adenine-Induced CKD Rat Model
Temporal Characterization of Mineral and Hormone Biomarker Profiles in Adenine-Induced CKD
CVRM Research Infographics
Download CVRM infographics featuring translational animal models, integrated research capabilities, and preclinical support services for cardiovascular, renal and metabolic drug discovery.
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Diet-Induced Obesity (DIO) Models
Comparative characterization study of three commercially available DIO models. -
Incretin Efficacy on DIO Models
Assessment of semaglutide and tirzepatide responsiveness in Inotiv’s DIO model. -
Preclinical Kidney Disease Research
Integrated models and translational endpoints supporting chronic kidney disease (CKD), diabetic nephropathy, acute kidney injury (AKI) and nephritis research. -
Rodent Cardiovascular Telemetry
Radio-telemetry capabilities for continuous monitoring of blood pressure, heart rate, ECG, temperature, and activity in freely moving rodents. -
Guinea Pig Model for Early Cardiovascular Risk Assessment
Telemetry-based guinea pig model supporting early cardiovascular safety assessment and QT prolongation characterization.
Heart Failure
Heart Failure
Inotiv provides translational rodent and large animal models, along with flexible research services and expert consultation, to accelerate heart failure drug discovery. Our in vivo pharmacology services deliver clinically relevant insights and robust efficacy data.
Hypertension and Vascular Disease
Hypertension and Vascular Disease
Inotiv supports drug discovery with in vivo models of hypertension and vascular disease that enable assessment of cardiac function, target identification, and compound efficacy. Our scientists design tailored studies and ensure comprehensive, goal-aligned testing.
Metabolic Disease
Metabolic Disease
Inotiv supports diabetes, obesity, and metabolic disease research with in vivo models and tailored pharmacology studies. Our translational models deliver clinically relevant insights, with expert guidance from study design to data interpretation to advance therapeutic development.
Pulmonary Disease
Pulmonary Disease
Inotiv provides in vivo models and pharmacology services to support pulmonary disease drug discovery. Our models reflect key features of obstructive, restrictive, and vascular conditions, enabling precise efficacy and safety assessment through customized, expert-guided studies.
Renal Disease
Renal Disease
Inotiv offers a diverse portfolio of rodent models of kidney disease and preclinical research services that support drug discovery efforts with clinically relevant and customizable solutions.
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