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Are you concerned about the health or genetic status of your research models? Inotiv's mouse and rat rederivation services provide a critical solution for researchers seeking to safeguard and revitalize their valuable rodent models. Utilizing advanced embryo transfer and IVF techniques, we can eliminate unwanted pathogens and genetic drift, ensuring the production of specific pathogen-free (SPF) animals. Rederivation from your cryopreserved embryos or sperm, is essential for researchers facing potential contamination risks, genetic inconsistencies or those needing to import or export animal models between laboratories or across biosecurity barriers. By entrusting your mouse rederivation or rat rederivation to us, you secure that the foundation for reliable and reproducible in vivo studies, maintaining the highest standards of animal and genetic integrity.

When you utilize our rederivation service, you can expect:

  • Comprehensive Rodent Rederivation: We offer embryo rederivation or hysterectomy rederivation utilizing your preferred breeders combined with genetic testing to ensure the preservation of your valuable animal model's genetics.
  • Rigorous Health Monitoring: Our health status evaluation employs customer-approved microbiologic monitoring profiles on foster or recipient females and offspring, guaranteeing specific pathogen-free (SPF) rodent models.
  • Pathogen Elimination: Through our meticulous process, we ensure the complete elimination of pathogenic and opportunistic microorganisms, safeguarding the integrity of your in vivo studies.
  • Unrestricted Animal Model Distribution: Rederivation eliminates distribution restrictions, enabling seamless collaboration with investigators and facilitating international animal model transfer.
  • Reduced Research Variability: Our services minimize variables that can affect research results, ensuring genetic consistency and enhancing the reliability of your rodent models.
  • Flexible Offspring Delivery: We offer flexible options, including direct delivery of offspring to your facility or colony expansion services at Inotiv, streamlining your animal model management.

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Rederivation services offered:

Service Requirements Project outcome

Rederivation with health screening (Your line can remain at Inotiv for colony maintenance and breeding or get shipped back to your facility.)

  • 5 donor males (6-27 wk)
  • 10 donor females (3-4 wk) or 15 wild-type donor females (3-4 wk)
  • Genotype of donors
  • Small cohort with a specified health status
  • Shipping and container fees are additional
  • Alternatively, maintain and breed colony through our Contract Breeding Services

Speed rederivation* with shipment of pregnant recipient females

  • 5 donor males (6-27 wk)
  • 10 donor females (3-4 wk) or 15 wild-type donor females (3-4 wk)
  • Genotype and background of donors
  • Minimum of 2-3 pregnant recipients females at 7-14 days post embryo transfer.
  • Health screening, shipping and shipping container fees are additional.

*Not available in all regions.  Please inquire.

Your project manager will work with you to customize a plan that best suits your objectives. Please download our contract breeding and support services brochure  indicating different options.

For more information on our services and to request a quote on your next project, please fill out our breeding questionnaire or contact us in North America at servicesPMG.US@inotiv.com or in Europe at servicesPMG.EU@inotiv.com.

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