Pde4b knockout rats
HsdSage:SD-Pde4bem1Sage
Strain
Location
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Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony
This model is a biallelic deletion of the Pde4b gene that regulates and mediates cellular responses to stimuli such as hormones and neurotransmitters. This model will be useful in the study of schizophrenia and bipolar disorder.
Origin:
The Pde4b Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.
Available regions:
For pricing information, please contact us using the phone number above.
Research use and related publications
- Neuroscience
- Bipolar disorder
- Neuronal growth and transport studies
- Neuroscience
- Schizophrenia
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