B-NDG knockout mice

• Autosomal recessive, single nucleotide polymorphism with Prkdc gene on chromosome 16
• Coat: Albino
• Common gamma chain gene (II2rg) interrupted
• Deficiency in cytokine signaling
• Deficient in T and B cells
• High humanization capability
• Lacks functional receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21
• Lacks NK cells
• Severe lymphocyte development impairment

Origin:

The B-NDG model is a single knockout mouse with an ultra immunodeficient phenotype. The model was generated by Biocytogen by deleting the IL2rg gene from NOD-scid mice.

Prkdc (protein kinase DNA-activated catalytic) null scid mutation is characterized by significantly deficient of functional T cells and B cells.

The Common gamma chain gene (IL2RG) deletion results in a lack of functional receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21, which results in the lack of functional NK cells.

Envigo, now Inotiv, licensed the mouse model from Biocytogen in 2019, where the model had been maintained. The model is albino.

Diet and Husbandry:

Inotiv’s iCare^TM Program focuses on creating industry awareness and continuing the highest-quality nutrition, bedding, and meaningful environmental enrichment for a wide range of laboratory animal species. Our iCare program supports the same standards of care we provide for our animal models while offering customers a convenient, single source for these essential products for their research facilities.

Diet:

The ideal lab animal diet is the 2918 Teklad Global 18% Protein Rodent Diet (Irradiated).

Bedding:

The preferred bedding product is Teklad Ultra Soft Bedding.

Enrichment:

The environmental enrichment products that are provided in a rotation include Teklad Diamond Twists, as well as Sizzle-Nest, Shelters, Cocoons, and Paper Wool from our welfareplus+^® line of enrichment products.

Model Support Services:
Inotiv offers related model support services to deliver research-ready models to your facility:

• Surgical Services
• Preconditioning Services
• Aging Services
• Contract Breeding Services
• Biospecimen Services

Health Monitoring Report Update
Inotiv is standardizing global health monitoring to deliver consistent, rigorous surveillance. Updated reports featuring our revised testing frequencies and agents will begin with the September 2026 cycle with reports becoming available between mid-September and early October.

Historical data for the previous 18 months will remain available under the Technical Resources tab. For details on monitored agents and testing frequencies, visit our Health Monitoring Reports page.  Please contact us if you have any questions or concerns.

• United States - Building 410 Denver, PA

Available regions:

I. For-Profit (Commercial) Female Order code: 126 - US

I. For-Profit (Commercial) Male Order code: 126 - US

II. Non-Profit (Academic) Male Order code: 126 - US

II. Non-Profit (Academic) Female Order code: 126 - US

• iCare Program: Continuity of Care — US
• Model information sheet
• Fighting mice data sheet
• Characterization, development, and applications of the novel ultra-immunodeficient B-NDG mouse
• Comparative tumor model study

Archived Health Monitoring Reports

• United States - Building 410 Denver, PA
• The Netherlands - B3 ISO B-NDG