hApoE3 knockin rats

• Background strain: Sprague Dawley

Availability: Live Colony
Zygosity genotype: Homozygous

Human apolipoprotein E (ApoE) is primarily present in the liver, kidney, and spleen, where it plays a critical role in cholesterol and lipid transport and metabolism. In the central nervous system, ApoE is synthesized and secreted by astrocytes, microglia, and neurons where it is involved in injury repair. Human ApoE (hApoE) exists as three major isoforms, ApoE2, ApoE3 and ApoE4, which are the products of three alleles at a single gene locus on the long arm of chromosome 19 in the human. hApoE2 is thought to be protective of AD, hApoE3 seems to be WT or neutral, and hApoE4 appears to yield a higher incidence for Alzheimer’s disease. In this hApoE3 knock-in rat, the rat endogenous ApoE codon region is replaced with the corresponding part of human ApoE3.

Origin:

Diet and Husbandry:

Inotiv’s iCare^TM Program focuses on creating industry awareness and continuing the highest-quality nutrition, bedding, and meaningful environmental enrichment for a wide range of laboratory animal species. Our iCare program supports the same standards of care we provide for our animal models while offering customers a convenient, single source for these essential products for their research facilities.

Diet:

The ideal lab animal diet is the 2018 Teklad Global 18% Protein Rodent Diet (Irradiated or Autoclavable).

Bedding:

The preferred bedding product is Teklad Corncob Bedding.

Enrichment:

The environmental enrichment products that are provided in a rotation include Teklad Diamond Twists, as well as Sizzle-Nest, Shelters, Cocoons, and Paper Wool from our welfareplus+^® line of enrichment products.

Model Support Services:
Inotiv offers related model support services to deliver research-ready models to your facility:

• Surgical Services
• Preconditioning Services
• Aging Services
• Contract Breeding Services
• Biospecimen Services

Health Monitoring Report Update
Inotiv is standardizing global health monitoring to deliver consistent, rigorous surveillance. Updated reports featuring our revised testing frequencies and agents will begin with the September 2026 cycle with reports becoming available between mid-September and early October.

Historical data for the previous 18 months will remain available under the Technical Resources tab. For details on monitored agents and testing frequencies, visit our Health Monitoring Reports page.  Please contact us if you have any questions or concerns.

• United States - Building 410 Denver, PA

Available regions:

For pricing information, please contact us using the phone number above.

• iCare Program: Continuity of Care — US
• Model information sheet 

Archived Health Monitoring Reports

• United States - Building 410 Denver, PA