Established Pharmacology and Toxicology Models

Disease Pharmacology is a core component of groundbreaking drug development and disease models provide a critical path to drug discovery success. These models provide invaluable study endpoints, guide research efforts, and drive decision making for innovative therapeutic interventions. Inotiv has established and provides access to a wide range of in vivo, preclinical early-stage research models combined with drug efficacy, pharmacology, and safety studies.

Our experienced team of scientists has the expertise to offer a wide range of study designs in pharmacology and toxicology within multiple therapeutic and disease indications including neuroscience, GI/IBD, inflammatory/immunology, cardio-renal, hepatic, pulmonary disease, and more. Our hands-on collaborative approach means that our scientists will work with you to learn your specific preclinical study requirements and assist you from initial study design to final reporting with dependable, reproducible results.

Cardiovascular Disease and Injury

Inotiv offers comprehensive cardiovascular models to evaluate therapeutic efficacy and safety, aiding in the development of treatments for heart-related conditions.

Main Cardiovascular Disease Page
Heart Failure
- Dilated Cardiomyopathy Models
- Diabetic Cardiomyopathy Models
- Hypertrophic Cardiomyopathy Models
- Experimental Autoimmune Myocarditis Models
Hypertension and Vascular Disease
- Hypertensive Heart Disease Models
- Pulmonary Arterial Hypertension (PAH) Models
- Vascular Leak Models

Gastrointestinal and Inflammatory Bowel Disease (IBD)

Our gastrointestinal models provide insights into digestive system disorders, including inflammatory bowel disease (IBD), facilitating the assessment of potential treatments for various conditions.

Liver Diseases And Injury

Inotiv's hepatic models are designed to study liver function and disease, supporting the development of hepatoprotective and other liver-targeted therapies.

Liver Diseases
- Liver Fibrosis Models
- Metabolic Dysfunction-Associated Steatohepatitis (MASH) Models
- Liver Regeneration Models
- Hepatitis B Models
- Acute Liver Injury Models
Main Cardiovascular Disease Page

Metabolic Diseases

Inotiv offers models that mimic metabolic and diabetic conditions, aiding in the discovery and testing of treatments for metabolic disorders.

Metabolic Diseases
- Type I Diabetes Models
- Type II Diabetes Models
- Obesity Models
- Metabolic Dysfunction-Associated Steatohepatitis (MASH) Models
Main Cardiovascular Disease Page

Neuroscience

Our neuroscience models support research into neurological disorders, enabling the assessment of neuroprotective and neurotherapeutic strategies.

Osteoarthritis (OA)

Inotiv’s OA models replicate key aspects of joint degeneration and inflammation, enabling evaluation of disease-modifying and symptomatic therapies.

OA Models

Other Inflammatory Conditions

Inotiv offers specialized models for a variety of inflammatory diseases, providing insight into complex immune pathways and supporting the development of targeted anti-inflammatory treatments.

Anemia
Psoriasis
Dermatitis
Delayed type hyper-sensitivity
Anaphylaxis
Peritonitis
Acute edema
Pancreatitis

Pain

Inotiv’s pain models support the evaluation of therapeutic candidates across a range of pain-related conditions, helping to advance the development of effective analgesic strategies.

Pharmacokinetic, Pharmacodynamic and Metabolic Sampling

Inotiv provides PK/PD and metabolic sampling services to characterize drug absorption, distribution, metabolism, and excretion, ensuring data-driven decisions in drug development.

Safety, Pharmacokinetics & Pharmacodynamics

Standard pharmacokinetic studies
Pharmacokinetic, pharmacodynamic and metabolic sample collection
Standard routes of administration: SC, PO, IP, IV, IA, IR, ID, ad libitum

Pulmonary Disease and Injury

Inotiv's pulmonary models facilitate the study of respiratory diseases, assisting in the development of treatments for various lung conditions.

Pulmonary Diseases
- Asthma Models
- Chronic Obstructive Pulmonary Disease (COPD) Models
- Idiopathic Pulmonary Fibrosis (IPF) Models
- Acute Lung Injury (ALI) Models
- Pulmonary Arterial Hypertension (PAH) Models
Main Cardiovascular Disease Page

Renal Disease and Injury

Our renal models are designed to study kidney function and disease, supporting the development of nephroprotective therapies.

Renal Diseases
- Acute Kidney Injury Models
- Chronic Kidney Disease Models
- Diabetic Kidney Disease Models
- Hypertensive Nephropathy Models
- Nephritis Models
- Nephrotic Syndrome Models
Main Cardiovascular Disease Page

Systemic Autoimmune Rheumatic Disease (SARD)

Inotiv’s models for SARDs mimic key features of conditions such as lupus and rheumatoid arthritis, enabling the assessment of immunomodulatory and disease-modifying therapies.

Scleroderma

Lupus

Rheumatoid arthritis

Monoarticular inflammation/arthritis

Toxicologic

Inotiv’s comprehensive toxicology services include in vivo and in vitro testing to assess safety profiles, identify potential adverse effects, and support regulatory submissions for preclinical development.

Non-GLP discovery toxicology
Regulated IND/CTA enabling

Cardiovascular Safety
- Cardiovascular Telemetry Platform – Continuous measurement of blood pressure, heart rate, ECG, respiration, temperature & activity in conscious, unrestrained animals for up to 6 months. Blood, urine, fecal and tissue sampling available.
- Infusion Pharmacology Platform – Continuous infusion of test compound and simultaneous blood pressure & heart rate analysis for up to 14 days. Clinical observations, blood, urine, fecal and tissue sampling
- Cardiac, Lipid and Metabolic Biomarkers – Markers of tissue and biochemical damage (e.g. CK, CRP, chol, trigs, glucose, HbA1c, etc.)
- Echocardiography – Left Ventricular Function & Dimensions
- Left Ventricular Function – +/-dP/dt, Tau, LVEDP and LVESP

Renal Safety
- Renal Function – Creatinine Clearance, GFR, proteinuria and electrolytes
- Kidney Histology – Glomerulosclerosis, tubular damage, fibrosis, etc.
- Renal Biomarker Panel – Analysis of FDA/EMA approved urinary biomarkers that are predictive of drug-induced renal toxicity and translatable to human nephrotoxicity

General Safety and Toxicology (non-GLP)
- Chronic Infusion Studies – Continuous infusion of test agent for up to 14 days. Clinical observations, blood, urine, fecal and tissue sampling
- Hematology – 23-parameter complete blood count plus 5-point WBC differential analysis on blood samples from in-life studies
- Clinical Chemistry – 180 analytes available including markers of liver, kidney, cardiac, pancreas and bone damage; as well as lipids, metabolic and inflammation
- Histopathology – Standard or tailored to your target tissue of interest

Gastrointestinal Safety and Function
- Intestinal Motility – Charcoal meal test
- Intestinal Secretion – Closed and Open loop models of fluid and electrolyte secretion as well as compound absorption